![]() ![]() The organophosphates are nonpersistent in the environment that is, after application they rapidly break down into relatively nontoxic substances. ![]() All may penetrate the intact skin but do not accumulate in body tissues as do many of the chlorinated hydrocarbon pesticides. They are widely used as insecticides, and all are cholinesterase inhibitors of varying potency. be avoided in patients with organophosphate poisoning (see PRECAUTIONS: DRUG INTERACTIONS). The organophosphate pesticides, a closely related family of chemicals, share a number of characteristics which are of considerable importance to the clinician. PROTOPAM (pralidoxime chloride) is indicated as an antidote. Open-label randomized clinical trial of atropine bolus injection versus incremental boluses plus infusion for organophosphate poisoning in Bangladesh. ![]() ![]() Accordingly, practicing physicians in all communities should know how to diagnose and treat organophosphate intoxication and how to advise patients on the principles of poisoning prevention. With administration of antidotes and intensive care at Charité-Universitätsmedizin Berlin, the man made a full recovery. That involvement is likely to increase, because recent governmental actions against the use of DDT and related organochlorine pesticides will likely increase the domestic and agricultural use of the organophosphate pesticides. Consider if patient presents within 60 minutes. The organophosphates are the pesticides most often involved in serious human poisoning. These therapies are also discussed in greater detail in the fifth edition of Recognition and Management of Pesticide Poisonings. ![]()
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